ESXi 6.5 introduces VMFS6, which supports both 512e and 512n devices.
What three configurations are supported when using these devices? (Choose three.)
A. Hosts with both 512e and 512n devices.
B. Storage vMotion between both 512e and 512n devices.
C. Datastore Extents spanned between both 512e and 512n devices.
D. Storage DRS clusters containing only both 512e and 512n devices.
Datastore Extents. A spanned VMFS datastore must use only homogeneous storage devices, either 512n, 512e, or 4Kn. The spanned datastore cannot extend over devices of different formats.
https://docs.vmware.com/en/VMware-vSphere/6.7/com.vmware.vsphere.storage.doc/GUID-7552DAD4-1809-4687-B46E-ED9BB42CE277.html