Home » NCLEX » NCLEX-PN » Narrow therapeutic index medications:
Narrow therapeutic index medications:
A. are drug formulations with limited pharmacokinetic variability.
B. have limited value and require no monitoring of blood levels.
C. have less than a twofold difference in minimum toxic levels and minimum effective concentration in the blood.
D. have limited potency and side effects.
Correct Answer: C
Explanation/Reference:
Explanation:
The therapeutic index is the ratio between the median lethal dose and median effective dose of a drug. It provides a general indication of the margin of safety of a drug. Choice 1 is incorrect because pharmacokinetics is the process of adsorption, distribution, metabolism, and elimination. Choice 2 is incorrect because narrow therapeutic index drugs require close monitoring since there is often little difference between the desired drug effect and toxicity. Choice 4 is incorrect because narrow therapeutic index drugs have the potential for severe toxic effects with only slight increases in the dose or slight decreases in elimination.Pharmacological Therapies
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