Home » NCLEX » NCLEX-PN » You should monitor this client for:
A client has been taking a drug (Drug A) that is highly metabolized by the cytochrome p-450 system. He has been on this medication for 6 months. At this time, he is started on a second medication (Drug B) that is an inducer of the cytochrome p-450 system. You should monitor this client for:
A. increased therapeutic effects of Drug A.
B. increased adverse effects of Drug B.
C. decreased therapeutic effects of Drug A.
D. decreased therapeutic effects of Drug B.
Correct Answer: C
Explanation/Reference:
Explanation:
Drug B induces the cytochrome p-450 enzyme system of the liver, thus increasing the metabolism of Drug A. Therefore, Drug A is broken down faster and exerts decreased therapeutic effects. Drug A is metabolized faster, thus reducing, not increasing, its therapeutic effect. Inducing the cytochrome p- 450 system does not increase the adverse effects of Drug B. Drug B induces the cytochrome p-450 system but is not metabolized faster. Thus, the therapeutic effects of Drug B are not decreased.Pharmacological Therapies
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